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KMID : 0370220200640050343
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Yakhak Hoeji
2020 Volume.64 No. 5 p.343 ~ p.349
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Review on the Synthesis and Biological Activities of Resveratrol and Its Derivatives
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Kim Cho-Rong
Lee Sang-Hyup
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Abstract
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Resveratrol, a type of phytoalexin found in many plants, is known to be a useful component for human health.
It is found in vegetables, fruits, wines and teas, and especially in grapes. Resveratrol has been reported to have variousmedicinal effects, such as anti-inflammatory, anti-cancer and anti-aging effects. In particular, anti-cancer effects are believedto be achieved by suppressing the growth of cancer cells and therefore, decreasing cancer organisms. Based on thisusefulness, extensive efforts to synthesize resveratrol have been continued. Some of the typical methods using Heckreaction, Perkin reaction and Wittig reaction have been reported, and further studies for improvement are still in progress.
Derivative syntheses by substituting hydroxy groups of resveratrol with alkyl or halogen groups were also performed alongwith investigation of biological properties of the related compounds. As a result, synthesis and biological evaluation ofresveratrol and its derivatives were discussed to assess and enhance the potential of resveratrol as a medicinal componentand/or a dietary supplement.
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KEYWORD
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Resveratrol, polyphenol, trihydroxystilbene, antioxidant, anticancer
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